Спеціалізована хімічна продукція

NFAT Inhibitor 1PC X 500UG // ІНГІБІТОР ЯДЕРНОГО ФАКТОРУ АКТИВОВАНИХ Т-КЛІТИН, 500МКГ. Номер в каталозі Sigma-Aldrich 480402-500UG Фасування 500МКГ. Температура зберігання −20°C Synonym: MAGPHPVIVITGPHEE, NFAT Inhibitor – Calbiochem, Empirical Formula (Hill Notation) C75H118N20O22S, Molecular Weight 1683.93 A highly selective NFAT (Nuclear Factor of Activated T-cells) inhibitor that interferes with calcineurin-NFAT interaction without affecting calcineurin (Cat. No. 539568) phosphatase activity. Inhibits NFAT activation and NFAT-dependent expression of endogenous cytokine genes in T cells, without affecting the expression of other cytokines that require calcineurin but not NFAT. A highly selective NFAT inhibitor that prevents NFAT activation and NFAT-dependent expression of endogenous cytokine genes in T cells. Does not affect the expression of other cytokines requiring calcineurin, but not NFAT. Inhibits calcineurin-mediated dephosphorylation of NFAT1, NFAT2, and NFAT4 in cell extracts.

Quercetin, >=95% (HPLC), solid // КВЕРЦЕТИН, >=95% (ВЕРХ), 10Г Номер в каталозі Sigma-Aldrich Q4951-10G Фасування 10Г. Температура зберігання room temp Synonym: 3,3′,4′,5,6-Pentahydroxyflavone, 2-(3,4-Dihydroxyphenyl)-3,5,7-trihydroxy-4H-1-benzopyran-4-one CAS Number 117-39-5, Empirical Formula (Hill Notation) C15H10O7 , Molecular Weight 302.24, PubChem Substance ID: 329823865 Quercetin is a flavonoid with anticancer activity. Quercetin is a mitochondrial ATPase and phosphodiesterase inhibitor. It Inhibits PI3-kinase activity and slightly inhibits PIP kinase activity. Quercetin has antiproliferative effects on cancer cell lines, reduces cancer cell growth via type II estrogen receptors, and arrests human leukemic T cells in late G1 phase of the cell cycle. Quercetin may also inhibit fatty acid synthase activity.

PARP Inhibitor I, 3-ABA 1PC X 100MG // ІНГІБІТOР I, PARP, 3-ABA, 100МГ Номер в каталозі Sigma-Aldrich 165350-100MG Фасування 100МГ. Температура зберігання 10-30 °C Synonym: PARP Inhibitor I, 3-ABA - CAS 3544-24-9 - Calbiochem, 3-Aminobenzamide CAS Number 3544-24-9,Empirical Formula (Hill Notation) C7H8N2O,Molecular Weight 136.15, MDL number MFCD00007989 The PARP Inhibitor I, 3-ABA, also referenced under CAS 3544-24-9, controls the biological activity of PARP. This small molecule/inhibitor is primarily used for Cell Structure applications. A cell-permeable anti-proliferative agent that acts as an inhibitor of poly(ADP-ribose) polymerase (PARP). Has minimal effect on bacterial toxin-mediated ADP-ribosylation. An inhibitor of UV-induced apoptosis. Also strongly inhibits K562 target cell killing by human effector natural killer cells..